Douglas McCreery is the Director of the Neural Engineering Program

Research interests

Physiologic and morphologic effects of chronic electrical stimulation of the central nervous system (current NIH funding)

Neurophysiology of microstimulation of sensory (auditory and visual) pathways in the central nervous system (current NIH funding)

Physiologic and morphologic effects of chronic electrical stimulation of the peripheral nerves, such as the vagus (prior NIH funding)

Development of hardware and software systems for multichannel electrical stimulation (prior NIH funding)

Degrees

B.S. in Electrical Engineering at the University of Connecticut, CT in 1966

Ph.D. in Biomedical Engineering at the University of Connecticut, CT in 1975

Bio-sketch

Dr. McCreery held a post-doctoral fellowship in the University of Minnesota, School of Medicine in 1975-1979. As a postdoctoral fellow, he evaluated the use of electrophysiological techniques in intraoperative neurosurgery. He arrived to HMRI in 1979I, and worked in the Neural Engineering Program (then called Neurological Research Program) ever since first as staff scientist, later a senior staff scientist, and since 2001 as the program director. He applied his skills in neurophysiology, software and hardware design, and microelectrode fabrication.

Accreditations

Member of the Society for Neuroscience.

Reviewer for the IEEE Transactions on Biomedical Engineering and IEEE Transactions on Neural Systems and Rehabilitation Engineering

Publications

[1] P. Rosenberg, L. T. Kremzner, D. McCreery, and R. E. Willette, "Inhibition of choline acetyltransferase activity in squid giant axon," Biochim Biophys Acta, vol. 268, pp. 49-60, 1972.

[2] J. R. Bloedel and D. B. McCreery, "Organization of peripheral and central pain pathways," Surg Neurol, vol. 4, pp. 65-81, 1975.

[3] D. B. McCreery and J. R. Bloedel, "Reduction of the response of cat spinothalamic neurons to graded mechanical stimuli by electrical stimulation of the lower brain stem," Brain Res, vol. 97, pp. 151-6, 1975.

[4] D. R. McCreery and J. R. Bloedel, "A quantitative approach to evaluating the effect of stimulating devices on the perception of noxious stimuli," Med Instrum, vol. 9, pp. 205-8, 1975.

[5] J. R. Bloedel, D. B. McCreery, and D. L. Erickson, "Analysis of the action of implanted stimulus devices using signal detection theory. pp. 433-7," In: Bonica JJ, et al., ed. Advances in pain research and therapy. New York, Raven Press, 1976.

[6] D. B. McCreery and J. R. Bloedel, "Effect of trigeminal stimulation on the excitability of cat spinothalamic neurons," Brain Res, vol. 117, pp. 136-40, 1976.

[7] D. B. McCreery and J. R. Bloedel, "A critical examination of the use of signal detection theory in evaluating a putative analgesic--transcutaneous electrical nerve stimulation," Sens Processes, vol. 2, pp. 38-57, 1978.

[8] A. J. Smith, D. B. McCreery, J. R. Bloedel, and S. N. Chou, "Hyperemia, CO2 responsiveness, and autoregulation in the white matter following experimental spinal cord injury," J Neurosurg, vol. 48, pp. 239-51, 1978.

[9] D. B. McCreery, J. R. Bloedel, and E. G. Hames, "Excitability changes in lumbosacral spinothalamic neurons produced by non-noxious mechanical stimuli and by graded electrical stimuli applied to the face," Brain Res, vol. 177, pp. 253-63, 1979.

[10] D. B. McCreery, J. R. Bloedel, and E. G. Hames, "Effects of stimulating in raphe nuclei and in reticular formation on response of spinothalamic neurons to mechanical stimuli," J Neurophysiol, vol. 42, pp. 166-82, 1979.

[11] T. G. Yuen, W. F. Agnew, L. A. Bullara, S. Jacques, and D. B. McCreery, "Histological evaluation of neural damage from electrical stimulation: considerations for the selection of parameters for clinical application," Neurosurgery, vol. 9, pp. 292-9, 1981.

[12] W. F. Agnew, T. G. Yuen, and D. B. McCreery, "Morphologic changes after prolonged electrical stimulation of the cat's cortex at defined charge densities," Exp Neurol, vol. 79, pp. 397-411, 1983.

[13] L. A. Bullara, D. B. McCreery, T. G. Yuen, and W. F. Agnew, "A microelectrode for delivery of defined charge densities," J Neurosci Methods, vol. 9, pp. 15-21, 1983.

[14] D. B. McCreery and W. F. Agnew, "Changes in extracellular potassium and calcium concentration and neural activity during prolonged electrical stimulation of the cat cerebral cortex at defined charge densities," Exp Neurol, vol. 79, pp. 371-96, 1983.

[15] W. F. Agnew, T. G. Yuen, D. B. McCreery, and L. A. Bullara, "Histopathologic evaluation of prolonged intracortical electrical stimulation," Exp Neurol, vol. 92, pp. 162-85, 1986.

[16] D. B. McCreery, L. A. Bullara, and W. F. Agnew, "Neuronal activity evoked by chronically implanted intracortical microelectrodes," Exp Neurol, vol. 92, pp. 147-61, 1986.

[17] W. F. Agnew and D. B. McCreery, "Considerations for safety in the use of extracranial stimulation for motor evoked potentials," Neurosurgery, vol. 20, pp. 143-7, 1987.

[18] D. B. McCreery, W. F. Agnew, and J. McHardy, "Electrical characteristics of chronically implanted platinum-iridium electrodes," IEEE Trans Biomed Eng, vol. 34, pp. 664-8, 1987.

[19] D. B. McCreery, W. F. Agnew, T. G. Yuen, and L. A. Bullara, "Comparison of neural damage induced by electrical stimulation with faradaic and capacitor electrodes," Ann Biomed Eng, vol. 16, pp. 463-81, 1988.

[20] W. F. Agnew, D. B. McCreery, T. G. Yuen, and L. A. Bullara, "Histologic and physiologic evaluation of electrically stimulated peripheral nerve: considerations for the selection of parameters," Ann Biomed Eng, vol. 17, pp. 39-60, 1989.

[21] W. F. Agnew, D. B. McCreery, T. G. Yuen, and L. A. Bullara, "Local anaesthetic block protects against electrically-induced damage in peripheral nerve," J Biomed Eng, vol. 12, pp. 301-8, 1990.

[22] W. F. Agnew and D. B. McCreery, "Considerations for safety with chronically implanted nerve electrodes," Epilepsia, vol. 31, pp. S27-32, 1990.

[23] D. B. McCreery, W. F. Agnew, T. G. Yuen, and L. Bullara, "Charge density and charge per phase as cofactors in neural injury induced by electrical stimulation," IEEE Trans Biomed Eng, vol. 37, pp. 996-1001, 1990.

[24] D. B. McCreery, W. F. Agnew, L. A. Bullara, and T. G. Yuen, "Partial pressure of oxygen in brain and peripheral nerve during damaging electrical stimulation," J Biomed Eng, vol. 12, pp. 309-15, 1990.

[25] D. B. McCreery, T. G. Yuen, W. F. Agnew, and L. A. Bullara, "Stimulation with chronically implanted microelectrodes in the cochlear nucleus of the cat: histologic and physiologic effects," Hear Res, vol. 62, pp. 42-56, 1992.

[26] D. B. McCreery, W. F. Agnew, T. G. Yuen, and L. A. Bullara, "Damage in peripheral nerve from continuous electrical stimulation: comparison of two stimulus waveforms," Med Biol Eng Comput, vol. 30, pp. 109-14, 1992.

[27] W. F. Agnew, D. B. McCreery, T. G. Yuen, and L. A. Bullara, "MK-801 protects against neuronal injury induced by electrical stimulation," Neuroscience, vol. 52, pp. 45-53, 1993.

[28] D. B. McCreery, T. G. Yuen, W. F. Agnew, and L. A. Bullara, "Stimulus parameters affecting tissue injury during microstimulation in the cochlear nucleus of the cat," Hear Res, vol. 77, pp. 105-15, 1994.

[29] D. B. McCreery, W. F. Agnew, T. G. Yuen, and L. A. Bullara, "Relationship between stimulus amplitude, stimulus frequency and neural damage during electrical stimulation of sciatic nerve of cat," Med Biol Eng Comput, vol. 33, pp. 426-9, 1995.

[30] J. P. Mobley, J. Huang, J. K. Moore, and D. B. McCreery, "Three-dimensional modeling of human brain stem structures for an auditory brain stem implant," Ann Otol Rhinol Laryngol Suppl, vol. 166, pp. 30-1, 1995.

[31] F. Portillo, P. Mobley, J. Moore, and D. McCreery, "Feasibility of a central nervous system auditory prosthesis: penetrating microelectrode insertion force studies," Ann Otol Rhinol Laryngol Suppl, vol. 166, pp. 31-3, 1995.

[32] B. J. Woodford, R. R. Carter, D. McCreery, L. A. Bullara, and W. F. Agnew, "Histopathologic and physiologic effects of chronic implantation of microelectrodes in sacral spinal cord of the cat," J Neuropathol Exp Neurol, vol. 55, pp. 982-91, 1996.

[33] D. B. McCreery, T. G. Yuen, W. F. Agnew, and L. A. Bullara, "A characterization of the effects on neuronal excitability due to prolonged microstimulation with chronically implanted microelectrodes," IEEE Trans Biomed Eng, vol. 44, pp. 931-9, 1997.

[34] D. B. McCreery, T. G. Yuen, W. F. Agnew, and L. A. Bullara, "A quantitative computer-assisted morphometric analysis of stimulation- induced injury to myelinated fibers in a peripheral nerve," J Neurosci Methods, vol. 73, pp. 159-68, 1997.

[35] R. V. Shannon, J. K. Moore, D. B. McCreery, and F. Portillo, "Threshold-distance

measures from electrical stimulation of human brainstem," IEEE Trans Rehabil Eng, vol. 5, pp. 70-4, 1997.

[36] D. B. McCreery, R. V. Shannon, J. K. Moore, and M. Chatterjee, "Accessing the tonotopic organization of the ventral cochlear nucleus by intranuclear microstimulation," IEEE Trans Rehabil Eng, vol. 6, pp. 391-9, 1998.

[37] W. F. Agnew, D. B. McCreery, T. G. Yuen, and L. A. Bullara, "Evolution and resolution of stimulation-induced axonal injury in peripheral nerve," Muscle Nerve, vol. 22, pp. 1393-402, 1999.

[38] X. Liu, D. B. McCreery, R. R. Carter, L. A. Bullara, T. G. Yuen, and W. F. Agnew, "Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes," IEEE Trans Rehabil Eng, vol. 7, pp. 315-326, 1999.

[39] D. B. McCreery, T. G. Yuen, and L. A. Bullara, "Chronic microstimulation in the feline ventral cochlear nucleus: physiologic and histologic effects," Hear Res, vol. 149, pp. 223-38, 2000.

[40] A. Prochazka, V. K. Mushahwar, and D. B. McCreery, "Neural prostheses," J Physiol, vol. 533, pp. 99-109., 2001.

[41] W. F. Agnew and D. B. McCreery, "Principles of safe and effective nerve stimulation," in New perspectives in sacral nerve stimulation, U. Jonas and V. Grunewald, Eds. London: Martin Dunitz, 2002, pp. 29-42.

[42] D. B. McCreery, W. F. Agnew, and L. A. Bullara, "The effects of prolonged intracortical microstimulation on the excitability of pyramidal tract neurons in the cat," Ann Biomed Eng, vol. 30, pp. 107-19., 2002.

[43] P. Troyk, M. Bak, J. Berg, D. Bradley, S. Cogan, R. Erickson, C. Kufta, D. McCreery, E. Schmidt, and V. Towle, "A model for intracortical visual prosthesis research," Artif Organs, vol. 27, pp. 1005-15, 2003.

[44] D. C. Bradley, P. R. Troyk, J. A. Berg, M. Bak, S. Cogan, R. Erickson, C. Kufta, M. Mascaro, D. McCreery, E. M. Schmidt, V. Towle, and H. Xu, "Visuotopic Mapping through a Multichannel Stimulating Implant in Primate V1," J Neurophysiol, 2004.

[45] S. F. Cogan, A. A. Guzelian, W. F. Agnew, T. G. Yuen, and D. B. McCreery, "Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation," J Neurosci Methods, vol. 137, pp. 141-50, 2004.

[46] P. S. Manoonkitiwongsa, R. L. Schultz, D. B. McCreery, E. F. Whitter, and P. D. Lyden, "Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis," J Cereb Blood Flow Metab, vol. 24, pp. 693-702, 2004.

[47] D. McCreery, V. Pikov, A. Lossinsky, L. Bullara, and W. Agnew, "Arrays for chronic functional microstimulation of the lumbosacral spinal cord," IEEE Trans Neural Syst Rehabil Eng, vol. 12, pp. 195-207., 2004.

[48] V. Pikov and D. B. McCreery, "Mapping of spinal cord circuits controlling the bladder and external urethral sphincter functions in the rabbit," Neurourol Urodyn, vol. 23, pp. 172-9, 2004.

[49] McCreery D, Lossinsky A, Pikov V, Liu X (2005) Microelectrode array for chronic deep brain microstimulation and recording. IEEE Trans Biomed Eng (in press)

E-mail: dougmcAThmriDOTorg