Panya Steve Manoonkitiwongsa is a neurohistologist, anatomist, electron microscopist, histochemist, and the head of the transmission electron microscopy and image analysis facilities of the Neural Engineering Program.

Research interests

- Therapeutic and contraindication effects of vascular endothelial growth factor (VEGF) for the treatment of ischemic stroke using anatomical (histotechnology, electron microscopy, enzyme cytochemistry, immunocytochemistry, image analysis, in situ hybridization, stereology) and molecular biology techniques.

- Application of computer instructional technology to the teaching of anatomical sciences (histology, neuroanatomy and gross anatomy).

Degrees

B.S. in Biology at Southern University, New Orleans, LA

M.S. in Biology at Andrews University, Berrien Springs, MI

Ph.D. in Anatomy at Loma Linda University, Loma Linda, CA

Certificate in Electron Microscopy at Microscopy Society of America, Chicago, IL

Certificate in Instructional Technology and in Computer Information Systems at the University of California, Riverside, CA

Bio-sketch

Dr. Manoonkitiwongsa completed two postdoctoral fellowships, one year at the Department of Pathology and Human Anatomy of Loma Linda University, Loma Linda, CA, and two years at the Department of Neuroscience of the University of California, San Diego, CA. As a postdoctoral fellow, he specialized in neuropathology, histochemistry, and quantitative electron microscopy (electron microscopy, image analysis and stereology). In the Neural Engineering Program, Dr. Manoonkitiwongsa is exploring the therapeutic potential and contraindication effects of vascular endothelial growth factor (VEGF) for the treatment of ischemic stroke. His attention is on translational research in developing safe and efficacious methods for ischemic stroke therapy using molecular histologic techniques. He was involved in the pioneer research in demonstrating the complications associated with VEGF-based angiogenesis therapy for the treatment of ischemic stroke.

Accreditations

- Reviewer for the Stroke journal.

Publications

Manoonkitiwongsa, P. S., R. L. Schultz, D. B. McCreery, Ernest F. Whitter, P. D. Lyden. Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be comprised by angiogenesis. Journal of Cerebral Blood Flow and Metabolism 24: 693-702, 2004

Manoonkitiwongsa, P. S., R. L. Schultz. Proper Nomenclature of Formaldehyde and Paraformaldehyde Fixatives for Histochemistry. Histochemical Journal 34: 365-367, 2002

Manoonkitiwongsa, P. S., R. L. Schultz, E. F. Whitter, P. D. Lyden. Use of image analysis for estimation of the numerical densities of neurons and synapses in cerebral cortex. Brain Research Protocols 8: 150-151, 2001

Manoonkitiwongsa, P. S., C. Jackson-Friedman, P. J. McMillan, R. L. Schultz, P. D. Lyden. Cerebral angiogenesis following stroke is correlated with increased numbers of macrophages: The "clean-up" hypothesis. Journal of Cerebral Blood Flow and Metabolism 21: 1223-1231, 2001

Manoonkitiwongsa, P. S., P. J. McMillan, R. L. Schultz, C. Jackson-Friedman, P. D. Lyden. A simple stereologic method for analysis of cerebral cortical microvessels using image analysis. Brain Research Protocols 8: 45-57, 2001

Manoonkitiwongsa, P. S., E. F. Whitter, W. Wareesangtip, P.J. McMillan, R. L. Schultz. Appropriate cytochemical controls for differentiation of calcium-specific ATPase from ecto-ATPase. Histochemical Journal 32: 759-760, 2000

Manoonkitiwongsa, P. S., R. L. Schultz, W. Wareesangtip, E. F. Whitter, P. B. Nava, P. J. McMillan. Luminal localization of blood-brain barrier sodium, potassium adenosine triphosphatase is dependent on fixation. Journal of Histochemistry & Cytochemistry 48: 859-865, 2000

Manoonkitiwongsa, P. S., E. F. Whitter, W. Wareesangtip, P. J. McMillan, P. B. Nava, R. L. Schultz. Calcium-dependent ATPase unlike ecto-ATPase is located primarily on the luminal surface of brain endothelial cells. Histochemical Journal 32: 313-324, 2000

Manoonkitiwongsa, P. S., E. F. Whitter, R. L. Schultz. An in situ cytochemical evaluation of blood-brain barrier Na+, K+-ATPase polarity. Brain Research 798: 261-270, 1998

E-mail: stevemanoonAThotmailDOTcom