 | ||||
 | ||||
 | | | | |
 | ||||
| | | | |
K. Shankar Narayan, PhD,
has been doing research at HMRI since 1969 and is the Senior Research Scientist in Cell Biology. Currently, he is studying Rhodamine-123 cytotoxicity in vitro and in vivo, and assisting in the clinical trials of Rhodamine-123 in prostate cancer patients.
A native of India, he studied agriculture at the University of Delhi, completed his masters at the University of Indian Agriculture Research Institute (I.A.R.I.) and received his doctorate degree at the University of Oklahoma. He was a research associate at the Central Rice Institute and I.A.R.I. in India then relocated to the United States, where he was a graduate research assistant at the University of Oklahoma and was a research assistant at Caltech in the biology division. As a postdoctoral fellow at Baylor University in Texas, he studied nucleolar structure and function in normal and malignant mammalian cells followed by a research fellowship at the Institute of Animal Genetics at the University of Edinburgh Scotland.
He is a member of the American Society of Cell Biology, Microscopy Society of America, American Association for the Advancement of Science, Society for In Vitro Biology, and the California Chapter Tissue Culture Association.
Relevant Publications:
Narayan, K.S., Muramatsu, M. and Busch, H. Ultrastructural studies on RNA and DNA components of isolated nucleoli of Walker 256 carcinosoma. Exptl. Cell Res. 41: 81, 1966.
Narayan, K.S. and Birnstiel, M.L. Biochemical and ultrastructural characteristics of ribonucleoprotein particles isolated from rat liver cell nucleoli. Biochem. Biphys. Acta 190: 470, 1969.
Narayan, K.S. and Rounds, D.E. Minute ring-shaped particles in cultured cells of malignant origin. Nature, New Biology 243: 146, 1973.
Narayan, K.S. and Hendren, N. Occurrence of minute ring-shaped nucleoprotein particles in culture media conditioned by mammalian cells. In Vitro 12: 430, 1976.
Narayan, K.S., Thompson, M.A. and Okigaki, T. Detection of oncornavirus-like particles in normal and tumorigenic rat liver cell cultures. Gann 67: 755, 1976.
Lechner, J.F., Narayan, K.S., Ohnuki, Y., Babock, M.S., Jones, L.W. and Kaighn, M.E. Replicative epithelial cell cultures from normal human prostate. J. Natl. Cancer Inst. 60: 797, 1978.
Kaighn, M.E., Narayan, K.S., Ohnuki, Y. and Lechner, J.F. Establishment and Characterization of a Human Prostatic Carcinoma Cell Line (PC-3). Investigative Urology, 17: 16-23, 1979.
Narayan, K.S., Young R., Waelder, S. and Landolph, J.R. Early detection of transformed cells in carcinogen treated C3H/10 T1/2 cultures with the scanning electron microscope. Proc. 3rd Intl. Cong. Cell Biol., p. 5133, 1984.
Narayan, K.S., Young, R., Heidelberger, C. and Landolph, J.R. Morphological correlates of transformation in C3H/10T1/2 mouse embryo cells. Carcinogenesis 5:885-894, 1984.
Arcadi, J.A., Narayan, K.S., Techy, G., Ng, C-P., Saroufeem, R.., Jones. L.W. Studies of Rhodamine-123: Effect on rat prostate cancer and human prostate cancer cells in vitro. J.of Surg. Onc. 59: 86-93, 1995.
Wildhirt, S., Dudek, R., Suzuki, H., Pinto, V., Narayan, K.S., Bing, R.J. Immunohistochemistry in the identification of nitric oxide synthase isoenzymes in myocardial infarction. Cardiovascular Research 29: 526-531, 1995.