Tests currently offered at the Molecular Oncology Laboratory include:

Hematologic Malignancies

• Immunoglobulin gene rearrangement
• T-cell receptor beta chain gene rearrangement
• BCL-2 t(14;18) translocation
• BCR-ABL t(9;22) translocation
• PML-RAR alpha t(15;17) translocation
• PBX1-E2A t(1;19) translocation
• MLL-1 gene rearrangement
• Bone marrow engraftment analysis using polymorphic markers

Solid Tumors

• H-, K-, and N-Ras oncogene mutation analysis
• N- and e-myc gene amplification
• HER-2/neu gene amplification
• Microsatellite (genomic) instability analysis
• LOH studies
• RET oncogene mutation analysis in MEN II and FMTC
• APC mutation analysis in FAP
• MSH2 and MLH1 mutation analysis in HNPCC
• p53 gene mutation analysis
• FISH analyses with unique sequence probes and alpha satellite probes

Specimen Requirements

All testing must be arranged before sending specimens by calling Dr. Faye Eggerding at (626) 795-4343.

Each sample must be accompanied by a completed test requisition form and be labeled with the patient's name, specimen type, and age of specimen collection. Blood or bone marrow samples should be collected in an EDTA (lavender top) tube and delivered overnight. Tissue may be sent fresh on ice or snap-frozen in liquid nitrogen and delivered overnight on dry ice.