Harrington Publications

1.  Durward, W. F. and Harrington, M. G.  1979.  Burning and the.inadequate management of epilepsy.  Br. Med. J. 2, 1218.

 2.  Harrington, M. G. and Bone, I.  1981.  Spinal meningioma presenting as focal epilepsy:  A case report.  Br. Med. J. 282, 1584-1985.

3.  Harrington, M. G. and Draper, I. T.  1981.  Post-influenzal.encephalitis and Reye's syndrome.  J. Neurol. Neurosurg. Psychiat. 44, 649.

4.  Harrington, M. G., Durward, W. F., and Simpson, J. A.  1981.  Renal.impairment and Acyclovir.  Lancet ii, 1281.

5.  Harrington, M. G., MacPherson, P., McIntosh, W. B., Allan, B. F.,.Bone, I.  1981. The significance of the incidental finding of basal ganglia.calcification on computed tomography.  J. Neurol. Neurosurg. Psychiat. 44,.1168-1170.

6.  Harrington, M. G., McGeorge, A. P., and Ballantyne, J. P.  1983.  A.prospective survey for insulinomas at the neurology clinic.  Lancet May 14,.1094-1095.

7.  Harrington, M. G., McGeorge, A. P., and Ballantyne, J. P.  1983.The effect of routine lumbar puncture on the electroencephalogram.  J.Neurol. Neurosurg. Psychiat. 46, 283-286.

8.  Harrington, M. G., McGeorge, A. P., and Behan, P. O.  1983.  The.specific treatment of reading epilepsy.  Irish J. Med. Sci. 152, 318-319.

9.  Gentleman, D. and Harrington, M. G.  1984.  Penetrating injury of.the spinal cord.  Injury 16, 7-8.

10.  Harrington, M. G., Merril, C. R., Goldman, D., Xu, X.-H., and.McFarlin, D. E.  1984.  Two-dimensional electrophoresis of cerebrospinal.fluid proteins in multiple sclerosis and various neurological diseases. Electrophoresis 5, 236-245.

11.  Merril, C. R., Harrington, M. G., and Alley, V.  1984.  A.photodevelopment silver stain for the rapid visualization of proteins.separated on polyacrylamide gels.  Electrophoresis 5, 289-297.

12.  Merril, C. R., and Harrington, M. G.  1984.  Development of silver.stains for the rapid visualization of protein alterations with applications to analysis of cerebrospinal fluid in diseases involving the central.nervous system.  In:  Electrophoresis '84, V. Neuhoff, (ed.).  Verlag.Chemie, Basel, pp. 321-323.

13.  Harrington, M. G. and Merril, C. R.  1984.  Two-dimensional.electrophoresis and "ultrasensitive" silver staining of cerebrospinal.fluids proteins in neurological diseases.  Clin. Chem. 30, 1933-1937.

14.  Merril, C. R. and Harrington, M. G.  1984.  "Ultrasensitive" silver.stains:  Their use exemplified in the study of normal human cerebrospinal fluid proteins separated by two-dimensional electrophoresis.  Clin. Chem. 30, 1938-1942.

15.  Harrington, M. G., Merril, C. R., and Torrey, E. F.  1985. Differences in cerebrospinal fluid proteins between patients with.schizophrenia and normal persons.  Clin. Chem. 31, 722-726.

16.  Merril, C. R. and Harrington, M. G.  1985.  The search for mitochondrial inheritance of human disease.  Trends in Genetics 1, 140-144.

17.  Wolf, R. O., Harrington, M. G., and Merril, C. R.  1985. Two-dimensional electrophoresis and silver staining of parotid salivary.proteins.  J. Dental Research 64, 327.

18.  Harrington, M. G. and Merril, C. R.  1985.  Additional.cerebrospinal fluid proteins found in schizophrenia and Creutzfeldt-Jakob.disease.  Psychopharm. Bull. 21, 361-364.

19.  Harrington, M. G., Merril, C. R., Asher, D., and Gajdusek, D. C. 1986.  Abnormal proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.  New Eng. J. Med. 315, 279-283.

20.  Merril, C. R., Harasewych, M. G., and Harrington, M. G.  1986. Protein staining and detection methods.  In:  Gel Electrophoresis of.Proteins, M. J. Dunn (ed.).  Wright, Bristol, pp. 323-362.

21.  Harrington, M. G. and Kennedy, P. G. E.  1987.  The clinical use of.cerebrospinal fluid studies in demyelinating neurological diseases. Postgrad. Med. J. 63, 735-740.

22.  Steven, A. C., Bisher, M. E., Harrington, M. G., and Merril, C. R. 1987.  All that glisters is not gold:  The physical basis of coloration in silver-stained gels.  In:  Proceedings of the 45th Annual Meeting of the.Electron Microscopy Society of America, G. W. Bailey, (ed.).  San Francisco.Press, San Francisco, CA, pp. 940-941.

23.  Merril, C. R., Bisher, M. E., Harrington, M. G., and Steven, A. C. 1988.  Coloration of silver-stained protein bands in polyacrylamide gels is caused by light scattering from silver grains of characteristic sizes. Proc. Natl. Acad. Sci. USA 85, 453-457.

24.  Marzewski, D. J., Towfighi, J., Harrington, M. G., Merril, C. R.,.and Brown, P.  1988.  Creutzfeldt-Jakob disease following pituitary-derived human growth hormone:  A new American case.  Neurology 38, 1131-1133.

25.  Croxson, M., Brown, P., Synek, B., Harrington, M. G., Frith, R.,.Clover, G., Wilson, J., and Gajdusek, D. C.  1988.  A new case of.Creutzfeldt-Jakob disease associated with human growth hormone therapy in.New Zealand.  Neurology 38, 1128-1130.

26.  Harrington, M. G. and Merril, C. R.  1988.  Cerebrospinal fluid analysis in diseases of the nervous system.  J. Chromatogr. 429, 345-358.

27.  Hochstrasser, D. F., Harrington, M. G., Hochstrasser, A.-C.,.Miller, M. J., and Merril, C. R.  1988.  Methods for increasing the resolution of two-dimensional protein electrophoresis.  Anal. Biochem. 173,.424-435.

28.  Hochstrasser, D. F., Harrington, M. G., Hochstrasser, A.-C., and.Merril, C. R.  1988.  Improved separation and detection of proteins with.retained background silver staining.  In:  Electrophoresis '88, C. Schafer-Nielsen (ed.), The Protein Laboratory, University of Copenhagen,.pp. 245-248.

29.  Merril, C. R., and Harrington, M. G.  1988.  Two-dimensional.electrophoresis of proteins in the study of schizophrenia.  Schizophorenia.Bulletin. NIMH 14, 249-254.

30.  Hochstrasser, A.-C., James, R. W., Martin, B. M., Harrington, M. G., Hochstrasser, D. F., Pometta, D., and Merril, C. R.  1988.  HDL.particle associated proteins in plasma and cerebrospinal fluid.  Appl. Theor. Electrophoresis 1, 73-76.

31.  Merril, C. R., Harrington, M. G., Sunderland, T. 1989. Plasma dehydroepiandrosterone levels in HIV infection.  JAMA 261 (8), 1149.

32.  Sunderland, T., Merril, C. R., Harrington, M. G., Lawlor, B. A.,.Molchan, S. E., Martinez, R., and Murphy, D. L.  1989.  Reduced plasma.dehydroepiandrosterone concentrations in Alzheimer's disease.  Lancet 2,.570.

33.  Merril, C. R., and Harrington, M. G.  1989.  Silver staining protein detection:   mechanisms and applications.  In:  Proceedings of the.International Two-Dimensional Electrophoresis Conference, Vienna, November.1988.  VCH Publishers, New York, pp. 243-255.  Eds. A. T. Endler and S. Hanash.

34.  Hood, L.E., Aebersold, R., Harrington, M., Hunkapillar, T., Kaiser,.R., Kent, S.B., Landegren, U., Nika, H..  Protein chemistry and the biotechnology of the future.  In: Methods in Protein Sequence Analysis,.536-553, 1989.

35.  Harrington, M. G.  1990.  Elution of protein from gels.  In:  Meth. Enzymol. 182, 488-495.

36.  Merril, C. R., Harrington, M. G., and Sunderland, T. 1990. Reduced plasma dehydroepiandrosterone concentrations in HIV infection and.Alzheimer's disease.  In:  The Biologic Role of Dehydroepiardrosterone.(DHEA).  Eds. Kalini and Regelson, Walter de Gruyter and Co.  pp 101-105.

37.  Blisard, K.S., Davis, L.E., Harrington, M.G., Lowell, J.K.,.Kornfeld, M., Berger, M.L.  1990. Pre-mortem diagnosis of Creutzfeldt-Jakob disease by detection of abnormal cerebrospinal fluid proteins.  J. Neurol. Sci., 99, 75-81.

38.  Voisin, P., Harrington, M. G., Weller, J. L., Goldman, D., Merril,.C. R., Klein, D. C.  1991, Noradrenergic control of the synthesis of two rat pineal proteins.  Brain Research, 517, 25-34.

39.  Harrington, M.G., Puckett, C., Hood, L., 1991, Simultaneous analysis of phosphoproteins and total cellular proteins from PC12 cells,.Methods: a Companion to Meth. Enzymol. 3, 135-141.

40.  Harrington, M.G., Gudeman, D., Zewert, T., Yun, M. and Hood, L.,.1991, Analytical and micropreparative two-dimensional electrophoresis of.proteins, Methods: a Companion to Meth. Enzymol. 3, 98-108.

41.  Harrington, M.G., 1991, Two-dimensional Electrophoresis. Methods: a.Companion to Meth. Enzymol. 3, 71-71.

42.  Harrington, M.G., Gudeman, D., Yun, M., Wu, W., Albright, R.,.Eberlein, S., Solomon, J., Hood, L., 1991.  The tissue, cellular and body.fluid origin of some disease-associated spinal fluid proteins.  In: 2D PAGE.'91, Ed M. J. Dunn, Zebra Printing, London, pp 218 and 322-325.

43.  Johnston, R.F., Barker, D.L., Pickett, S.C., Puckett, C., Solomon,.J., Hood, L., Harrington, M.G., 1991.  Double-label analysis of.phosphoproteins using storage phosphor imaging of 2D gels.  In: 2D PAGE.'91, Ed M. J. Dunn, Zebra Printing, London, pp 53-57.

44.  Harrington, M.G., Coffman, J.A., Calzone, F.J., Hood, L.E.,.Britten, R.J., Davidson, E.H., 1992, Complexity of sea urchin embryo.nuclear proteins that contain basic domains.  Proc. Natl. Acad. Sci. USA,.89, 6252-6256.

45.   Zewert, T., Harrington, M.G., 1992, Polyhydroxy and.polyethyleneglycol (Meth)Acrylate Polymers: Physical properties and general.studies for their use as electrophoretic matrices.  Electrophoresis, 13,.817-824.

46.  Zewert, T., Harrington, M.G.,1992, Polyethyleneglycol Methacrylate 200 as an electrophoresis matrix in hydroorganic solvents.Electrophoresis, 13, 824-831.

47.  Yun, M., Wu, W., Hood, L., Harrington, M. G., 1992, 1992 Human.Cerebrospinal Fluid Protein Database.  Electrophoresis, 13, 1002-1013.

48.  Zewert, T., Harrington, M.G., 1993, Protein electrophoresis.Current Op. Biotechnology,  4, 3-8.

49.  Harrington, M.G., Aebersold, R., Martin, B.O., Merril, C.R., Hood,.L., 1993, Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein.  Applied and Theor. Electrophoresis, 3,.229-234.

50.     Solomon J., Harrington, M.G., 1993, A robust, high-sensitivity algorithm for automated detection of proteins in two-dimensional.electrophoresis gels.  CABIOS, 9, 133-139.

51.  Char, B.R., Bell, J.R., Dovala, J., Coffman, J.A., Harrington,.M.G., Becerra, J.C., Davidson, E.H., Calzone, F.C., Maxson, R., 1993,.SpOct, a gene encoding the major octamer binding protein in sea urchin.embryos: expression profile, evolutionary relationships, and DNA binding of.expressed protein.  Devel. Biol., 158, 350-363.

52.  Harrington, M.G., Lee, K., Yun, M., Zewert, T., Bailey, J., Hood,.L., 1993, Mechanical precision in two-dimensional electrophoresis can improve spot positional reproducibility.  Applied and Theor. Electrophoresis, 3, 347 353.

53.  Harrington, M.G., Lee, K.H., Bailey, J.E., Hood, L.E., 1994,.Sponge-like electrophoresis media: mechanically strong materials compatible with organic solvents, polymer solutions and two-dimensional.electrophorsis.  Electrophoresis, 15, 187-194.

54.  Harrington, M.G. and Zewert, T.E., 1994, Poly (ethylene glycol).methacrylate-acrylamide copolymer media for hydrophobic protein and low temperature electrophoresis. Electrophoresis, 15, 195-199.

55.  Smith, L.C., Harrington, M.G., Britten, R.J., Davidson, E.H., 1994,.The sea urchin profilin gene is specifically expressed in mesenchyme cells during gastrulation.  Develop. Biol., 164, 463-474.

56   Zeller, R.Z., Coffman, J.A., Harrington, M.G., Britten, R.J.,.Davidson, E.H., 1995, SpGCF1,  A sea urchin  embryo DNA-binding protein, exists as five nested variants encoded by a single mRNA.  Develop. Biol.,.169, 713-727.

57  Lee, K.H., Harrington, M.G., Bailey, J.E., 1996.  Two-dimensional.electrophoresis of proteins as a tool in the metabolic engineering of cell cycle regulation.  Biotechnology & Bioengineering.  Biotech. And Bioeng.,.15, 336-340.

58  Hsich, G., Kenney, K., Gibbs Jr., C., Lee, K.H., and Harrington,.M.G. 1996.  The 14-3-3 Brain Protein in Cerebrospinal Fluid as a marker for transmissible spongiform encephalopathies.  The New England Journal of.Medicine, 335, 924-930.

59  Xian, J., Harrington, M.G., Davidson, E.H., 1996. DNA-protein.binding assays from a single sea urchin egg: A new, high-sensitivity capillary electrophoresis method.  Proc. Natl. Acad. Sci. USA. Proc. Nat'l. Acad. Sci., 93, 86-90.

60  Lee, K. H., Harrington, M. G., 1996.  Premortem diagnosis of Creutzfeldt-Jakob Disease by crebrospinal fluid analysis.  Lancet, 348,.887.

61  Isaacson, S. H., Keney, K. L., Gibbs Jr., C. J., Gajdusek, D. C.,.and Harrington, M.G.  1996.  Clinical Utility of Cerebrospinal Fluid Electrophoresis in Creutzfeldt-Jakob Disease.  Annals of Neurology, 40,.502.

62  Will, R. G., Zeidler, M., Brown, P., Harrington, M. G., Lee, K. H.,.and Kenney, K. L.  1996.  Cerebrospinal-fluid test for new-variant.Creutzfeldt-Jakob disease. Lancet, 348, 955.

63   Lee, K. H., Harrington, M. G. 1997.  The assay development of a molecular marker for transmissible spongiform encephalopathies. Electrophoresis, 18, 502-505.

64  Lee, K.H., Harrington, M.G. 1997. 14-3-3 and BSE.  Veterinary Record, 140, 206-207.

65  Harrington, M. G., Coffman, J. A., and Davidson, E. H. 1997. Covalent variation is a general property of transcription factors in the sea urchin embryo.  Molecular Marine Biology and Biotechnology, 6(3), 153-162.

66  Xian, J., Harrington, M.G.  Mobility shift analysis of protein-DNA complexes by capillary electrophoresis. In press.

67  Zewert, T., Harrington, M. G., Crosslinked Poly(N-acetylethylenimine) as an Isoelectric Focusing Matrix. Electrophoresis.  In press.

68  Coffman, J. C., Kirchhamer, C. V., Harrington, M. G., and Davidson, E. H., SpRUNT-1, a new member of the runt-domain family of transcription factors, is a positive regulator of the aboral ectoderm-specific CyIIIA gene in sea urchin embryos.  Development.  In press.

69  Lee, K. H., Harrington, M. G., Preparative Gel Electrophoresis. Gel Electrophoresis of Proteins - A Practical Approach (3rd Edition).  In press.

70  Coffman, J.A., Kirchhamer, C.V., Harrington, M.G., and Davidson, E.H.  SpMyb functions as a short range transcriptional  repressor to regulate spatial expression of CyIIIa in sea urchin embryos. In press.

Patents:

1. US # 4,892,814.  Harrington, M. G., Merril, C. R., Asher, D., and Gajdusek, D. C. Method for distinguishing Creutzfeldt-Jakob disease from other dementias.

2. US # 5,290,411. Zewert, T. and Harrington M.G..  Acrylic polymer electrophoresis medium.

3. US # 5,338,428.  Zewert, T., Harrington, M.G., Poly(N-Acylalkylenimine) electrophoresis support media.

4. US # 5,637,202.  Harrington, M.G. and Lee, K.H., Porous electrophoresis sponges.

5. US # 5,837,116. Harrington, M.G. and Packard D., Two-dimensional Electrophoresis Apparatus.

6. US # 08/630,961. Hsich, G., and Harrington, M.G., Method of detecting transmissible spongiform encephalopathies.