Fonteh Publications

1. Gibbons WA, Fonteh AN and McBride K.  Chemistry and Biotechnology of Biologically Active Natural Products: Proceedings of the 4th International Conference, Budapest 1987, Ed. C. Czantay, Hungarian Publishing Co., and  Elsevier, Amsterdam) pp 265-267, 1988.

2. Fonteh AN, McBride K and Gibbons WA.  Fundamental roles for ethanolamine and choline lipids in cell excitation and transmembrane signalling; anaesthesia.  Peptides 1988; proceedings of the 20th European Symposium (Ed Jung , G and E. Bayer; Walter de Gruyter, Berlin.) pp 670-672, 1989.

3. Fonteh AN, McBride K and Gibbons WA.  The inhibition of lipid methyltransferase by linear alcohols and disprofol.  Biochem Soc Transactions 17:721-722, 1989.

4. Gibbons WA, Fonteh AN and McBride K.  New criteria for, and a biochemical theory of, both general and local anaesthetics.  Biochem Soc Transactions  17:722-723, 1989.

5. Fonteh AN and Gibbons WA.  Solubilization and purification of lipid methyltransferase.  Biochem Soc Transactions 18:266-267, 1990.

6. Nakumara T, Fonteh AN, Hubbard WC, Triggiani M, Nagaki NL, Ishizaka T, and Chilton FH.  Arachidonic acid metabolism during antigen and ionophore activation of the mouse bone marrow

7. Fonteh AN and Chilton FH.  Rapid remodeling of arachidonate from phosphatidylethanolamine to phosphatidylcholine pools during mast cell activation.  J. Immunol. 148:1784-1791, 1992.

8. Delolmo E, Toth I, Fonteh AN, and Gibbons WA.  Lipid methyl transferase inhibiting activity of novel alpha-amino alkylic acid derivatives.  Int J Pharmaceutics 81(2-3):267-269, 1992.

9. Triggiani M, Fonteh AN, and Chilton FH.  Factors that influence the proportion of platelet-activating factor and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine synthesized by mast cells.  Biochem J 286:497-503, 1992.

10. Fonteh AN, and Chilton FH.  Mobilization of different arachidonate pools and their roles in the release of free arachidonic acid and in leukotriene biosynthesis.  J Immunol  150:563-570, 1993.

11. Chilton FH, Patel M, Fonteh AN, Hubbard WC and Triggiani M.   Dietary n-3 fatty acids effects on neutrophil lipid composition and mediator production: Influence of duration and dosage.  J Clin Invest 91:115-122, 1993.

12. Fonteh AN, Winkler JD, Torphy TT, Heravi J, Undem BJ, and Chilton FH.  Influence of adenosine 3',5'-monophosphate content on platelet activating factor biosynthesis in the human neutrophil.  J Immunol 151:390-401, 1993.

13. Gibbons WA, Auchi L, McBride K, Fonteh AN, Baafshe L, Tsvetnitsky V, Anderson MM, and Yebooah FA.  The purification and molecular weight determination of rat liver microsomal phospholipid N-methyltransferase.  Biochem Soc Transactions 21:449, 1993.

14. Fonteh AN, Bass DA, Samet JM, Seeds M, Marshall LA, and Chilton FH.  Evidence that secretory phospholipase A2 (sPLA2) plays an important role in arachidonic acid (AA) release and eicosanoid biosynthesis in mast cells.  J Immunol 152:5438-5447, 1994.

15. Diez M, Winkler J, Chilton FH and Fonteh AN.  Fatty acid and phospholipid selectivity of different phospholipase A2s using mammalian membranes as substrates.  Biochem J 301:721-726, 1994.

16. Diez M, Winkler J, Chilton FH and Fonteh AN.  Fatty acid and phospholipid selectivity of different phospholipase A2s using mammalian membranes as substrates.  Biochem J 301:1023-1023, 1994.

17. Chilton FH, Fonteh AN, Iberico M, Bass DA, and Triggiani M.  Natural occurrence, synthesis, catabolism and biological activity of 1-acyl-2-acetyl-sn-glycero-3- phosphocholine.  J Lipid Med 10:47-51, 1994.

18. Winkler J, Fonteh AN, Sung C-M, Huang L, Hickey DMB, Torphy J, Griswold DE, Marshall LA, and Chilton FH.  Inhibition of CoA-independent transacylase as a novel means of control of eicosanoid formation and anti-inflammatory.  Adv Prostaglandins Thromboxane Leukotr Res 23:89-91, 1995.

19. Chilton FH, Fonteh AN, Sung C-M, Huang L, Hickey DMB, Torphy J, Griswold DE, Marshall LA, and Winkler JD.  Inhibition of CoA-independent transacylase as a novel means of control of eicosanoid formation and anti-inflammatory.  Biochemistry 34:5403-5410, 1995.

20. Fonteh AN, Samet JM, and FH Chilton.  Regulation of arachidonic acid, eicosanoids and phospholipases in murine mast cells by recombinant stem cell factor.  J Clin Invest 96:1432-1439, 1995.

21. Samet JM, Fasano MB, Fonteh AN, and Chilton FH.  Selective induction of prostaglandin G/H synthase I by stem cell factor and dexamethasone in mast cells.  J Biol Chem 270:8044-8049, 1995.

22. Winkler JD, Fonteh AN, Sung C-M, Heravi JD, Nixon AB, Chabot-Fletcher M, Griswold D, Marshall LA, Chilton FH.  Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators.  J Pharmacol Exp Ther 274:1338-1347, 1995.

23. Chilton FH, Fonteh AN, Surette ME, Triggiani M, Winkler JD.  Control of arachidonate levels within inflammatory cells.  Biochem Biophys Acta, 1299: 1-15, 1996.

24. Chilton FH, Averill FJ, Hubbard WC, Fonteh AN, Triggiani M, Lui M.  Antigen-induced generation of lyso-phospholipids in human airways. J Exp Med 183:2235-2245, 1996.

25. Samet JM, Fonteh AN, Galli SJ, Tsai M, Chilton FH:  Alterations in arachidonic acid metabolism in mouse mast cells induced to undergo maturation in vitro in response to stem cell factor J Allergy Clin Immunol 97:1329-1341, 1996.

26. Chilton-Lopez T, Surette ME, Swan DD, Fonteh AN, Johnson MM, Chilton FH.  Metabolism of gammalinolenic acid in human neutrophils. J Immunol 156:2941-2947, 1996.

27. Winkler JD, Surette ME, Fonteh AN, Chilton FH:  The key roles played by CoA-independent transacylase in arachidonate movement and inflammatory cell functions.  Pharmacol Rev Commun 8:19-27, 1996.

28. Samet JM, Madden MC, Fonteh AN.  Characterization of a secretory phospholipase A2 in human bronchoalveolar lavage fluid.  Exp Lung Res 22:299-315, 1996.

29. Surette ME, Winkler JD, Fonteh AN, Chilton FH.  Relationship between arachidonate-phospholipid remodeling and apoptosis.  Biochemistry 35:9187-9196, 1996.

30. Johnson MM, Swan DD, Surette ME, Chilton Lopez T, Fonteh AN, Chilton FH.  The in vitro metabolism of gammalinolenic acid in healthy humans.  J Nutr 127:1435-1444, 1997.

31. Fonteh AN, Samet JM, Surette ME, Reed W, Chilton FH.  Mechanisms that account for the selective release of arachidonic acid from whole cells by secretory phospholipase A2.  Biochim Biophys Acta 1398:253-266, 1998.

32. Chilton FH III, Chilton FH Jr, Clay CE, Trimboli A, Fonteh AN. Influence of arachidonic acid metabolism on cell proliferation and apoptosis.  In:  Winkler JD, ed.  Apoptosis and Inflammation.  Switzerland:Birkhauser Verlag Basel, pp. 19-38, 1999.

33. Surette ME, Fonteh AN, Bernatchez C, Chilton FH.  Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells.  Carcinogenesis 20:757-763, 1999.

34. Fonteh AN.  Assessment of arachidonic acid distribution into phospholipids of inflammatory cells.  Methods Mol Biol 120:77-89, 1999.

35. Fonteh AN, Reed W, Samet JM.  Determination of phospholipase A2s expression in mast cells by reverse-transcriptase polymerase chain reaction.  Methods Mol Biol 120:91-105, 1999.

36. Clay CE, Namen AM, Willingham MC, High KP, Kute TE, Trimboli AJ, Fonteh AN, Dawson PA, Chilton FH.  Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells.  Carcinogenesis 20:1905-1911, 1999.

37. Johnson MM, Vaughn B, Triggiani M, Swan DD, Fonteh AN, Chilton FH.  Role of arachidonyl triglycerides within lipid bodies in eicosanoid formation by human polymorphonuclear cells.  Am J Respir Cell Mol Biol 21:253-258, 1999.

38. Trimboli AJ, Waite BM, Atsumi G-I, Fonteh AN, Namen AM, Clay CE, Kute TE, High KP, Willingham MC, Chilton FH.  Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells.  Cancer Res 59:6171-6177, 1999.

39. Chilton FH, Fonteh AN, Johnson MM and Surette ME.  Metabolism of arachidonic acid.  In: Crystal, West and Barnes, eds.  Lung:  Scientific Foundations, Lippincott-Raven Publishers, Chapter 6, pp. 77-88 , 1999.

40. Winkler JD, Sung C-M, McCord M, Fonteh AN, Marshall LA, Chilton FH.  Inhibitors of coenzyme A-independent transacylase and effects on PAF production.  In:  Nigan G, Kunkel SM, Prescott SM, Vargaftig BB, eds.  Platelet-activating factor and related lipid mediators in health and disease. 2000

41. Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH.  Addition of eicosapentaenoic acid to g-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans.  J Nutr 130:1925-1931, 2000.

42. Fonteh AN, Atsumi G, LaPorte T, Chilton RH.  Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells.  J Immunol 165:2773-2782 (2000).

43. Clay CE, Namen AM, Fonteh AN, Atsumi, G., High, KP, Chilton FH15-deoxy-Delta(12,14)PGJ92) induces diverse biological responses via PPAR gamma activation in cancer cells. Prostaglandins and Other Lipid Mediators. 62(1) 23-32 (2000)

44. Fonteh AN, LaPorte T, Swan D, McAlexander MA.  A decrease in remodeling accounts for the accumulation of arachidonic acid in murine mast cells undergoing apoptosis.  J Biol Chem. 276   (2):1439-1449  (2001).

45. Clay,C.E.; Namen,A.M.; Atsumi,G.; Trimboli,A.J.; Fonteh,A.N.; High,K.P.; Chilton,F.H.. Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells. J.Investig.Med. 49(5) 413-420 (2001)

46. Fonteh,AN, Barham, BJ., Atsumi, G., Marion, CR., Edens, MB., Samet, JM., High, KP., and Chilton, FH.  Enhancement of mast cell survival; A novel function of some secretory phospholipase A2 isotypes.  J. Immunol. (in press)

47. Fonteh,AN. Differential effects of Arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils:  Evidence of different arachidonate pools.  Biochemistry (submitted)